From Genome to Therapy

From Genome to Therapy

Integrating New Technologies with Drug Development

Bock, Gregory R.; Goode, Jamie A.; Cohen, Dalia

John Wiley & Sons Inc

09/2000

174

Dura

Inglês

9780471627449

15 a 20 dias

380

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Introduction (J. Venter).

Electrophoresis-Based Fluorescent Dideoxy-Terminator Sequencing (J. Efcavitch).

Genomic Impact on Pharmaceutical Development (J. Venter).

From Transcription Regulation to Cell Cycle Checkpoint (R. Cai, et al.).

Mass Spectrometry Resurrects Protein-Approaches in Functional Genomics (M. Mann).

A Clinical Molecular Scanner to Study Human Proteome Complexity (D. Hochstrasser, et al.).

From Proteomics to Functional Analysis (J. van Oostrum, et al.).

Microbial Genome Sequencing: New Insights into Physiology and Evolution (C. Fraser).

Pharmacogenetics and Pharmacogenomics in the Discovery and Development of Medicines (A. Roses).

Mutagenesis and Genomics in the Mouse: Towards Systematic Studies of Mammalian Gene Function (S. Brown).

Biological Annotation of the Drosophila Genome Sequence (G. Rubin).

Applications of High-Density Oligonucleotide Arrays (R. Lipshutz).

Plasmodium Falciparum: From Genomic Sequence to Vaccines and Drugs (S. Hoffman & D. Carucci).

Functional Analysis of the Yeast Genome by Precise Deletion and Parallel Phenotypic Characterization (E. Winzeler, et al.).

Patenting Genes and Gene Therapy: Legal and Ethical Aspects (J. Straus).

Ethical Issues: From Genome to Therapy (D. Magnus).

The Impact of Genomics on Drug Discovery (P. Goodfellow).

From Genome to Therapy: Industry Perspective (P. Herrling).

Final General Discussion.

Indexes.
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advances; genetic; acceleration; technological; data; ability; rapid; programmes; known; place; organisms; many; sequences; sequencing; online; increase; speed; come; new technologies; accomplished; complete; greater; time; drugs